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Since February 2005, after the approval by the Ethics Committee, 40 patients and 68 healthy volunteers have been measured. A correlation study between iron overload and blood serum-ferritin concentration in the patient population attained a correlation coefficient R~0.68. Comparison with measurements of LIC via SQUID susceptometry on a subset of 30 patients participating in the present study (carried out by Dr. A. Piga at Ospedale S. Anna, Torino, Italy) yields a correlation coefficient R~0.77. Four patients (3 thalassemia major, 1 hereditary hemochromatosis) under intensive iron depletive therapy have been measured at least twice; our estimate of liver iron reduction is compatible with the clinical data (R~0.81). Comparison with LIC measured via biopsy is in progress. All comparisons were blinded.
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